The Dunwoody Labs AIMS profiles is the only test on the market that measures both IgG and immune complexes containing the complement fragment complement (C3d), for multiple food antigens and actually reports it. Random serum samples were measured for dietary allergen specific immunoglobulin using the Amplified Immunological Monitoring System (AIMS). AIMS are optimised for the for the semi-quantitative measurement of human immunoglobulins IgA, IgE, IgG, IgG4 and IgM in serum samples using an indirect ELISA (enzyme linked immunosorbent assay). The system also is capable of detecting immune complexes that contain the complement markers C3D or C1q.
Complement Activation The AIMS Profile measures complement activation for multiple foods. Complement activation is well-defined in the research as not only a cause of inflammation, but one of the strongest causes. The complement pathway acts as the body’s SWAT team to aggressively attack and clear threats, such as bacteria, viruses, protozoa, and allergens. It is part of our innate system, meaning that we are born with this immune defence mechanism.
Complement components patrol the blood harmlessly, but in an instant can go on the attack to kill and remove dangerous molecules from the body. When activated, the complement pathway sets off a domino effect of inflammatory cytokines, mast cell degranulation, and cell membrane destruction. It is a powerful protective force but can damage tissues if not kept under control. Complement is a quantifiable, reliable biomarker of tissue inflammation.
Complement serves as a link between the innate and adaptive immune response. This is because complement uses immunoglobulins to help identify dangerous molecules that should be destroyed. IgG1, IgG3, and IgM can activate complement.
IgG Subclasses 1–4 Immunoglobulin G (IgG) is the main immunoglobulin circulating in human blood and helps protect us from infection and outside antigens. There are four subclasses: IgG1, IgG2, IgG3, and IgG4. IgG1 responds to new food antigens. IgG2 and IgG3 react to cell surface oligosaccharides of viruses, protozoa, and foods, which can be allergenic. IgG4 is commonly related to delayed food sensitivity symptoms. IgG can also activate the complement system to recruit an inflammatory response. The AIMS Food Sensitivity Profile measures total IgG (subclasses 1-4) antibodies for 88 foods.